Through discourse with international groups of physicians, we conducted a cross-cultural analysis of the types of ethical dilemmas physicians face. Qualitative analysis was used to categorise the dilemmas into seven themes, which we compared among the physicians by country of practice. These themes were a-theoretically-driven and grounded heavily within the text. We then subjected the dilemmas to an analysis of moral intensity, which represents an important theoretical perspective of ethical decision making. These constructs represent salient determinants of ethical behaviour and (...) our cross-cultural sample afforded us the opportunity to consider both the pragmatic aspects of culture, as they are perceived by physicians, as well as the theory-driven concept of moral intensity. By examining both culture and moral intensity, we hope to better elucidate the complexities of ethical decision-making determinants among physicians in their daily practice. Doing so may potentially have practical implications for ethics training of medical students and foreign physicians. (shrink)

A pure vehicle theory of the contents of consciousness is not possible. While it is true that hard-wired tacit representations are insufficient as content-vehicles, not all tacit representations are hard-wired. The definition of stability offered for patterns of neural activation is not well-motivated, and too simplistic. We disagree in particular with the assumption that stability within a network is purely intrinsic to that network. Many complex forms of stability within a network are apparent only when interpreted by something external to (...) that network. The requirement for interpretation introduces a necessary functional element into the theory of the contents of consciousness, suggesting that a pure vehicle theory of those contents will not succeed. (shrink)

The digital shift leads to increasing changes. Employees can deal with changes through informal learning that enables needs-based development. For successful informal learning, self-regulated learning is crucial, i.e., to set goals, plan, apply strategies, monitor, and regulate learning for example by applying resource strategies. However, existing SRL models all refer to formal learning settings. Because informal learning differs from formal learning, this study investigates whether SRL models can be transferred from formal learning environments into informal work settings. More precisely, are (...) all facets relevant, and what are the relational patterns? Because informal workplace learning occurs through interaction with the context, this study investigates the influence of context, i.e., organizational learning culture and job characteristics on SRL. Structural equation modeling of N = 170 employees in various industries showed the relevance of the self-reported metacognitive strategies planning, monitoring, and regulation; the resource strategies help-seeking and effort regulation; and deep processing strategy elaboration. However, there was no evidence for organization strategies. The learning strategies were associated with self-efficacy and mastery-approach goal orientation. Regarding context, results supported indirect effects over self-motivational beliefs of learning strategies. Organizational learning culture was connected with mastery-approach goal orientation, whereas job characteristics autonomy and feedback were related to self-efficacy, which were again related to SRL strategies. Therefore, context can empower employees not only to accomplish their tasks but to develop themselves by applying SRL strategies. The results are discussed, and practical implications are outlined. (shrink)

This festschrift dedicated to Wilfrid Sellars is divided into two parts. Part I consists of eleven critical studies written expressly for this volume. They explore various aspects of Sellars’ philosophic thought. Part II, entitled "Sellarsiana," consists of Sellars’ autobiographical reflections, a bibliography of his works and a new series of papers by him on the problem of knowledge.

Perfect Paperbount Trim: 6 X 9 Text throught No halftones, No bleeds Update Print/Year line to read for year 2001, 6th printing.

Altruism is generally accepted to be the practice of unselfish concern for the well-being of others coupled with an associated measure of personal cost. Altruism as an actionable treatise for living aims to benefit society. While altruistic acts have traditionally been viewed as virtuous, in some cases, positive outcomes might not be forthcoming if the actor is not enlightened about the consequences of specific courses of action. While this precept has been argued extensively in historical commentary, no formal definition exists (...) for it. This article terms this concept as ‘unenlightened altruism’. The article reviews the scant extant discourse on ‘unenlightened altruism’ in scholarly literature, provides a formal definition for the ideology, opines consequentialist implications and correlates it to related ethical constructs. From the consequentialist standpoint, it is argued that it might be more ethical not to act than to act out of unenlightened altruism. (shrink)

This long-awaited new edition contains eight of the dialogues of Plato, and is the first in a new five-volume complete edition of his works in the OCT series.

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

How are we to reconcile the existence of a good and omnipotent God with the existence of suffering? The simplest solution is to see all suffering as chastisement for sin. But this solution comes up against the difficulty that the good sometimes suffer and the impious sometimes prosper. ….

In his work on the Redemption Professor Richard of the Faculty of Theology of Lyons presents us with the mature fruit of many years of study and lecturing. He touches on all the aspects of a very complicated theme with that mastery and security that can come only through long years of study and meditation.

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

Evolutionary developmental biology (evo-devo) has undergone dramatic transformations since its emergence as a distinct discipline. This paper aims to highlight the scope, power, and future promise of evo-devo to transform and unify diverse aspects of biology. We articulate key questions at the core of eleven biological disciplines—from Evolution, Development, Paleontology, and Neurobiology to Cellular and Molecular Biology, Quantitative Genetics, Human Diseases, Ecology, Agriculture and Science Education, and lastly, Evolutionary Developmental Biology itself—and discuss why evo-devo is uniquely situated to substantially improve (...) our ability to find meaningful answers to these fundamental questions. We posit that the tools, concepts, and ways of thinking developed by evo-devo have profound potential to advance, integrate, and unify biological sciences as well as inform policy decisions and illuminate science education. We look to the next generation of evolutionary developmental biologists to help shape this process as we confront the scientific challenges of the 21st century. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:64. ON HUME'S IS-OUGHT THESIS The famous thesis of Hume about "is" and "ought" I take to be, as I believe it has generally been taken to be: (1) For any factual statement e and any ethical statement h, h is not deducible from e. My object in these brief notes is neither to defend nor to attack (1), but just to point out certain mistakes which have been (...) made, or are apt to be made, about (1), or about what Hume's thesis is. A. Max Black has taken Hume's thesis to be that "only statements of fact can follow- from statements of facti* ¡ a thesis, Black thinks, which Popper and "many other philos c be ; osophers" believe. That is. Black took Hume's thesis to (2)For any factual e and any non-factual h, h is not deducible. from e. It is certain, however, that Popper does not believe (2), and I hope it is untrue that many other philosophers believe it. For (2) is obviously false, and on the contrary, every factual statement has at least one nonfactual consequence; since from any factual statement 'f, the statement *f or not-f, which is not factual, is deducible. But this leaves Hume's thesis (1) untouched, since there is no excuse for confusing it with the foolish thesis (2). B. If a statement h is not deducible from a statement e, then given e, the falsity of h is possible; or in other words, h has less than maximum probability in relation to e. So part at least of the content of Hume's thesis (1) is: (3)For any factual e and ethical h, P(h/e). (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)